Brain Health, Everyday Health, General, Healthy Ageing, Nutrition
22nd September 2011 by SevenSeasLife | 0 Comments
Humans evolved on a diet of polyunsaturated fats which are essential to our body’s health. Our ancestors ate a diet of these fats in proportion: Omega 3 : Omega 6 i.e. 1:1. Yet our modern western diet contains very highs quantities of Omega 6 and lower proportions of Omega 3, estimated at 15:1-16.7:11. Current medical research suggests that this dominance of Omega 6 to Omega 3 contributes to the development of many common diseases including cardiovascular disease, some cancers, inflammatory and autoimmune diseases.
Fish Oil is our richest dietary source of the essential fat Omega 3. Many other food sources contain omega 3 but neither in such concentration, quantity nor in the most useful forms – called Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) as Omega 3 fish oil. These polyunsaturated fats are made by our body from plant-sourced Omega 3. This conversion is limited by dietary and lifestyle choices including high saturated fat intake, high intakes of caffeine, stress, smoking and some health concerns e.g. viral infection plus genetic factors3. One in three of us does not like eating fish2, and therefore should consider supplementation. So significant are the research findings on the health benefits of Omega 3, that the Food Standards Agency changed their recommendations for consumption of oily fish from 1-2 portions a week to one to four for healthy adults (two for pregnant and lactating women) in 20044. You may be interested in reading more on the health benefits of Omega 3 in the diet.
Fish Oil is without a doubt good for your heart and arteries; this has been repeatedly shown in research. A trial of over 84,000 nurses for 16 years demonstrated that deaths related to cardiovascular disease were 50% lower in women who ate fish 5 times a week and 20% lower for those who ate fish one to three times a month5. Equally 2000 men aged 70+ who had survived a heart attack were studied, the group advised to add two to three portions of oil fish into their diet showed a 29% reduction in any further cardiac events6. A similar trial of over 11,000 participants reached similar conclusions using omega 3 supplementation7. The levels of Omega 3 are now believed to be the new measure of the health of a person’s heart and circulatory system8. Supplementing Omega 3 fatty acids has consistently been found to lower levels of triglycerides in the body9. Omega 3 supplementation with statins has shown significantly decreased cholesterol levels versus medicating with statins alone10. In summary, supplementing with Omega 3 and in particular the EPA and DHA in fish oil has been shown to benefit all types of cardiovascular diseases including heart attack, stroke and coronary artery disease11
The form of Omega 3 found in fish oils has been shown to reduce the production of the inflammatory chemical (Arachidonic Acid) in the body, which reduces inflammation of, for example, the joint in the inflammatory condition rheumatoid arthritis12. Logically the same effect occurs throughout the body and therefore Omega 3 fats, EPA and DHA are vital in the reduction of inflammation in inflammatory conditions, which include Crohn’s Disease, ulcerative colitis, psoriasis, asthma, lupus and cystic fibrosis. The evidence for the use of Omega 3 supplements for these conditions is mixed and needs further study. Supplementation with Fish Oil for pain relief of non-specific neck and back pain compared with non-steroidal anti-inflammatory drugs e.g. ibuprofen showed fish oil to be as effective, without the unpleasant side effects (gastric ulcers, bleeding, heart attack)13. The markers tested by doctors to show that the body is suffering from chronic inflammation have been shown to reduce with the use of Omega 3 supplementation, for example in patients suffering from Chronic Obstructive Pulmonary Disease (COPD) (an ‘umbrella’ term for people with chronic bronchitis, emphysema)14. It is widely accepted that Omega 3 fats behave as anti-inflammatories in the body.
Use of fish oil has been shown to slow the development of arthritis and the severity of symptoms including reduced pain, duration of morning stiffness and lowered use of non-steroidal anti-inflammatory drugs e.g. ibuprofen15.
Recent research has shown that young men with higher blood levels of Omega 3 have significantly denser bones, a measure of bone health and strength16. Animal studies have shown a lower ratio of Omega 6: Omega 3 in the diet reduces post-menopausal bone loss17; the results on the few studies carried out on humans were mixed although these also used high levels of Omega 618. More research is needed in this area.
Sixty percent of the human brain is fat. DHA as found in fish oil, makes up over 20% of this19. The development of a foetus’s brain requires high levels of DHA which is taken from the mother during pregnancy, leaving the mother at risk of a deficiency – and if levels are very low, the foetus20. A 2002 study found that mothers with lower levels of DHA in their breast milk after the birth and lower reported fish consumption, were more likely to suffer from post-natal depression20. Results of trials using Omega 3 in the treatment of clinical depression have shown statistically significant but mixed (usually due to inconsistencies in dose, time of trial and sample base) results according to the Journal of Psychiatry, which recommends that Omega 3 treatment for depression should be pursued21. Lower levels of DHA at birth have been shown to influence the likelihood of problem behaviour in children at the age of 722. Mothers who ate fish four times a week during pregnancy had babies with higher developmental scores at 18 months vs. those who ate no fish23.
Analysis of the brains of those who died with Alzheimer’s disease shows that they have lower levels of Omega 3 than those did not have the condition24. A review of Omega 3 and dementia completed in 2006 suggested that the beneficial effects were not proven25; however a more recent study in Alzheimer’s and Dementia 2010 showed significant benefits for learning and memory in 485 people suffering from age related cognitive decline26.
Omega 3 fats form the structural foundation of every cell membrane in the body, they are necessary for the production of hormones, regulation of our immune system, development and effective working of our brain, effective reproduction and central to the integrity of ever barrier (e.g. our skin or gut) with the outside environment. Omega 3 and Omega 6 fats are crucial for the workings of our body – we are made of them! The balance of Omega 3 to Omega 6 has radically changed in the Western diet. Having insufficient quantities of Omega 3 has been linked with an increased chance of diseases including poor heart and circulatory health, mental decline e.g. dementia, mental health (e.g. depression and schizophrenia), asthma, arthritis and some cancers27. In addition adequate intake of Omega 3 by pregnant women has been linked with better brain28 and eye function29 in their children. Whilst the quantities of Omega 3 supplementation needed to reverse symptoms for individual diseases is still in debate, it is clear that eating enough Omega 3 and reducing the amount of Omega 6 in your diet will increase your likelihood of good health. Omega 3 is not known to have any negative impact on health.
More Omega-3 articles
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Omega 3 Fish Oil? - Is fish oil the same as Omega 3
References:
1. Simpoulos A.P, 2008, The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases, Experimental Biology and Medicine, 233:674-688
2. Seven Seas Picture of Health Survey. 3,000 surveyed. November 2010-January 2011
3. Lindmark L, 2010, Omega 3 and Fish Oils. Not Just for a healthy heart. Lecture attended.
4. Scientific Advisory Committee on Nutrition (SACN), 2004, Advice on fish consumption: benefits and risks. London: Food Standards Agency
5. Hu FB, Bronner L, Willett WC, Stampfer MJ, Rexrode KM, Albert CM, Hunter D, Manson JE, 2002, Fish and Omega 3 intake and risk of coronary heart disease in women, Journal of American Medical Association, 287:1815-1821
6. Burr ML, Fehily AM, Gilbert JF, Rogers S, Holliday RM, Sweetnam PM, Elwood PC, Deadman NM, 1989, Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial, Lancet, 2:757-761
7. GISSI, 1999, Dietary supplementation with n-2 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell’Infarto miocardio, Lancet 354:447-455
8. Von Schacky C, 2009, Cardiovascular disease prevention and treatment, Prostaglandins, Leukotrienes and Essential Fatty Acids, 81:193-198
9. Phillipson BE, Rothrock DW, Connor WE, Harris WS, Illingworth DR., 1985, Reduction of plasma lipids, lipoproteins, and apoproteins by dietary fish oils in patients with hypertriglyceridemia. New EngIand Journal of Medicine, 312:1210-6
10. Bays HE, McKenny J, Maki KC, Doyle RT, Carter RN, Stein E, 2010, Effects of Prescription Omega-3-Acid Ethyl Esters on Non—High-Density Lipoprotein Cholesterol When Co-administered With Escalating Doses of Atorvastatin, Mayo Clinic Proceedings February 2010 85:2:122-128
11. Psota TL, Gebauer SK, Kris-Etherton P, 2006, Dietary Omega-3 Fatty Acid Intake and Cardiovascular Risk, American Journal of Cardiology, 98:3-18
12. Simopoulos AP, 2002, Omega-3 fatty acids in inflammation and autoimmune diseases, Journal for American College of Nutrition, 21:495-505
13. Maroon JC, Bost JW, 2005, ω-3 Fatty acids (fish oil) as an anti-inflammatory: an alternative to nonsteroidal anti-inflammatory drugs for discogenic pain, Surgical neurology, 65:326-331
14. Matsuyama W, Mitsuyama H, Watanabe M, Oonakahara K, Higashimoto I, Osame M, Arimura K, 2005, Effects of Omega-3 Polyunsaturated Fatty Acids on Inflammatory Markers in COPD, Chest, 128:3817-3827
15. Calder P, 2008, Joint Nutrition Society and Irish Nutrition and Dietetic Institute Symposium on ‘Nutrition and autoimmune disease’ PUFA, inflammatory processes and rheumatoid arthritis, Proceedings of the Nutrition Society, 67:409-418
16. Högström M, Nordström P, Nordström A, 2007, n–3 Fatty acids are positively associated with peak bone mineral density and bone accrual in healthy men: the NO2 Study1,2,3, American Journal of Clinical Nutrition, 85:803-807
17. Sun D, Krishnan A, Zaman K, Lawrence R, Bhattacharya A, Fernandes G., 2003, Dietary n_3 fatty acids decrease osteoclastogenesis and loss of bone mass in ovariectomized mice. Journal of Bone Mineral Research, 18:1206 –16
18. Vanek C , Connor WE, 2007, Do n_3 fatty acids prevent osteoporosis?, American Journal of Clinical Nutrition, 85:647-648
19. Crawford and Sinclair, 1972, Nutritional Influences in the evolution of the mammalian brain, Ciba Foundation Symposium (1971), Ed K Elliot and J Knight, 267-292 cited Lindmark L, 2010, Omega 3 and Fish Oils. Not Just for a healthy heart. Lecture attended.
20. Hibbeln JR, 2002, Seafood consumption, the DHA content of mother’s milk and prevalence rates of postpartum depression a cross-national, ecological analysis, Journal of Affected Disorders, 69:15-29
21. Pao-Yen L, Kuan-Pin S, 2007, A Meta-Analytic Review of Double Blind, Controlled Trials of Antidepressant Efficacy of Omega 3 Fatty Acids, Journal of Clinical Psychiatry, 68:1056-1061
22. Krabbendam L, Bakker E, van Os J, 2007, Relationship between DHA status at birth and child problem behaviour at 7 years of age, Prostaglandins, Leukotrienes and Essential Fatty Acids, 76:29-34
23. Daniels JL, Longnecker MP, Rowland AS, Golding J and ALSPAC Study Team, 2004, Fish Intake during pregnancy and early cognitive development of offspring, Epidemiology, 15:394-402
24. Corrigan FM, Horrobin DF, Skinner ER, Besson JAO, Cooper MB, 1998, Abnormal content of n−6 and n−3 long-chain unsaturated fatty acids in the phosphoglycerides and cholesterol esters of parahippocampal cortex from Alzheimer’s disease patients and its relationship to acetyl CoA content, The International Journal of Biochemistry and Cell Biology, 30:197-207
25. Freeman MP, Hibbeln JR, Wisner KL, Davis JM, Mischoulon D, Peet M, Keck PE, Marangell LB, Richardson AJ, Lake J, Stoll AL, 2006, Omega 3 Fatty Acids: Evidence Basis for Treatment and Future Research in Psychiatry, Journal of Clinical Psychiatry, 67:1954-1967
26. Yurko-Mauro K, McCarthy D, Rom D, Nelson EB, Ryan AS, Blakwell A, Salem N, Stedman M on behalf of MIDAS Investigators, 2010, Beneficial effects of docosahexaenoic on cognition in age-related cognitive decline, Alzheimer’s and Dementia, 6:456-464
27. Seafish. Sponsored by the four UK government fisheries departments; promotes good quality, sustainable seafood. www.seafish.org
28. Lands B, 2008, A critique of paradoxes in current advice on dietary lipids, Progress in Lipid Research, 47:77-106
29. Willatts C, Forsyth JS, DiModugno MK, Varma S, Colvin M, 1998, Effect of long-chain polyunsaturated fatty acids in infant formula on problem solving at 10 months of age, Lancet, 352:688-691
Bilbiography
X Phillipson BE, Rothrock DW, Connor WE, Harris WS, Illingworth DR., 1985, Reduction of plasma lipids, lipoproteins, and apoproteins by dietary fish oils in patients with hypertriglyceridemia. New EngIand Journal of Medicine, 312:1210-6.
Y Bays HE, McKenny J, Maki KC, Doyle RT, Carter RN, Stein E, 2010, Effects of Prescription Omega-3-Acid Ethyl Esters on Non—High-Density Lipoprotein Cholesterol When Co-administered With Escalating Doses of Atorvastatin, Mayo Clinic Proceedings February 2010 vol. 85 no. 2 122-128
Z Psota TL, Gebauer SK, Kris-Etherton P, 2006, Dietary Omega-3 Fatty Acid Intake and Cardiovascular Risk, American Journal of Cardiology, 98:3-18
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